该剧讲述了主角作为一个拥有长生不老能力的奇人异士，跨越千年的经历，以及对生命意义的深刻思考。剧中不仅探讨了人性善恶、道德伦理，还展现了主角如何运用古老的能力在现代世界中生存，并与之对抗的故事。
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全63集主角接到父亲电话，得知自己是个千亿富二代还被打款十亿要求花完，好尽快接受自己的身份回来继承产业，主角拿着钱去找女主，要还欠了五年的房租。被女主关心，主角内心温暖。且得知女主产业遇到困难，前往帮助。
全60集男科医生司音与科技公司创始人顾时迁的爱恨纠葛。两人大学时因贺孟阳伪造记录及司音父亲给出的家庭压力分手，多年后两人在诊室重逢，结果又因为重重误会而分开，贺孟阳与顾时迁的商业对手苏文婷联手，对两人多次设计陷害，挑拨二人关系，制造误会。苏文婷为了和顾时迁结婚，用尽了一切手段，害得司音失去了声音。贺孟阳为了得到司音，陷害顾时迁患上不育。顾时迁为救父、保公司一度妥协，司音屡遭险境，每次都凶险逃脱，始终未放弃真相。最终，顾时迁识破所有阴谋，救出被贺孟阳囚禁的司音，澄清过往误会。恶人皆受惩罚，司音恢复了声音，治愈顾时迁
全72集林峰作为一代神医之后，被林无双强行灌输医术进大脑，在黑水村痴傻了三年。三年后偶遇苏清月，鼻血冲开脑血栓后恢复正常，后帮苏清月救治苏大龙，但作为大姐的苏安安，却想联合张世豪将苏大龙下毒害死，然后栽赃嫁祸给林峰和苏清月。后得知苏安安开设的污水工厂，将污水管道埋在村子地底，还想谋夺家产。为揭露其阴谋，关闭污水厂，林峰将计就计，让苏大龙假死，苏安安露出马脚，最终，苏安安等人被抓，林峰和苏清月走到一起。
8.0全70集前世，荫蓼错信穿越者林怀月和驸马陆长凌，惨遭背叛，父皇被弑，国家倾覆，自己毁容后被林怀月用高跟鞋钉死在大牢。忠诚于她的魑魉将军得知死讯，率十万铁骑欲为她殉葬，却被林怀月设计阻挠。重生回到大离五十二年，荫蓼带着前世记忆，决心改写悲剧。她先救下被构陷的魑魉，以真心化解其怨恨，将这把“最忠诚的刀”收为己用；又拉拢东海质子萧越，为其铺路，使其成为日后助力。
10.0全64集沈洛白天是出租车司机，晚上是行侠仗义的黑面侠。某一日里，他救下一对姐妹花中的方雪，方雪请求他救自己的姐姐方晴，过程中沈洛得知姐妹花方雪和方晴竟是自己战友的妹妹。姐姐对他芳心暗许，妹妹崇拜他，他该如何抉择？
全35集小女孩与妈妈生活，生活艰辛却一直不被奶奶接纳，一次去奶奶家里时阻止了同父异母的弟弟受伤，又遭奶奶误解，又遇弟弟摔伤，母女俩送去医院过程中受到奶奶的百搬阻拦，恶毒奶奶却以为是自己的孙女，却不知是自己偏心的孙子已经有生命危险
全79集江雾惜作为真千金，被倪丽萍误认是小三之女虐待打骂，养母瘫痪去世后，她在林安妮生日宴得知真相，于是扮保姆混入林家，勾引林耀深、傅时砚，还利用对自己情根深种的楚放。最终将小三与奸夫一网打尽。
6.0全70集扬州杂货郎之女蓝玉与北平王世子秦烨幼时一玉定情，却因秦烨回京途中意外失忆、两人的信物阴差阳错被七公主楚嫣所得，秦烨因此认错了心上人。十年后，蓝玉以军医身份前往军营重逢秦烨，却在一夜春风后得知秦烨已经心有所属...
全81集21世纪医学博士沈予欢，穿越成1977年未婚妈妈，独自带娃四年。孩子生父谢廷川寻来，两人解开心结成婚。赴京后，沈予欢凭医术化解危机、打脸造谣者，进医院展才华，获大佬认可，最终捐医术药方，成医学界新星，与谢廷川相守幸福。
10.0全79集精英律师许清雾为报养育恩接受商业联姻，错认浪荡子岑渡为未婚夫，婚检才知对象是严谨冷酷的岑西淮，仓促领证。婚后她遇双重风暴，岑西淮以行动守护，二人打破契约冰冷，真心相爱。
全61集妻子杜碧淑被做局亏光家产，股神顾申非但没有责怪，反而带她再入证券交易所。仇家华彩云、林宇豪见状再起贪念，殊不知已踏入顾申的反做局陷阱，瞬间倾家荡产！不甘失败的二人投靠了顾申的宿敌薛志阳，并绑架其妻，逼迫顾申进行一场绝境赌斗。