该剧讲述了主角在经历无数磨难后，在命运的转角处邂逅真爱，共同面对生活挑战的故事。主角从艰难的家庭环境中奋斗，在成长过程中遇到各种人物，逐渐领悟到幸福的真谛。最终，他与如晨曦般温暖的女主角相遇，两人相互
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全80集剧中，沈南珩为医院高材生，与陆家三位千金共同创业，期间因男助理宋怀恩挑拨而遭遇误解。宋怀恩偷取其新药并反诬沈南珩，三位女主起初偏信谗言，导致沈南珩被逼离公司。即便沈警告新药存在副作用，众人仍执意发布，最终可能面临严重后果，情节由此展开深层矛盾与情感冲突。
全60集恶毒女配沈娇娇在与男主季宴礼的新婚之日，被他设计车祸同归于尽。两人同时重生回大学初遇时，并都能看到揭露剧情走向的弹幕。沈娇娇惊觉前世自己用金钱“资助”季宴礼（实则是交易）的行为，最终导致自己惨死。她决定彻底改变命运，放弃对季宴礼的执着。沈娇娇则带着神秘的新“男友”赵裴箫，开始了远离渣男、追求新生的道路，弹幕观众也因剧情偏离预期而困惑不已，一场大战即将爆发。
8.0全83集男主穿书成炮灰顾言，回忆起书中自己的悲惨结局，当即决定抱大腿。向全书最大反派盲女冷清秋求亲。竟意外获纯爱战神眷顾，他冒生命危险与冷清秋谈纯爱，让对方频频脸红，疯狂纯爱大反派女主，让女主直呼受不了。
全82集纪繁星遭掉包，假千金纪明月夺其身份，未婚夫助纣为虐，生母将她关精神病院致其惨死。重生回被诬陷夜，她向厉景琛宣主权，暗恋她的厉景琛将她宠上天。她一心复仇，厉景琛甘愿被利用，终打动她，两人共赴幸福。
全80集现代女博士秋月因意外穿越到古代，成为一名宫女。她利用自己的医学知识，成功治好了皇上的顽疾，从而获得关注。然而，她也因此卷入了复杂的宫廷斗争和情感纠葛中。秋月不仅撞脸太子青梅竹马，还与皇子之间产生了情感纠葛，面对各种挑战和困境，她凭借智慧和勇气，最终实现了自我成长和逆袭。
全36集东省地下势力黑龙会会长周震天为给父亲治病，隐瞒身份将周父送进医院。诈骗团伙姐弟佳丽、佳泽盯上周父，先以&quot;特效药&quot;骗走五万元，又伪造儿子坐牢骗局骗取其毕生积蓄和传家宝。在逼老人跳楼骗保的关键时刻，周震天发现异常及时赶来。
8.0全88集苏墨遵师命下山“了尘缘”，街头救下被追堵的许文珊，意外被她选中领证挡婚。他隐藏实力入职许文珊公司，以阳门十八针救杨老、解化工厂怪病，还卷入阴物争夺。为救体内藏血莲的许文珊，他集齐九阴之物，对抗阴煞门与毒医门。最终破境成神，铲除反派，开启了甜蜜又热血的新生活。
6.0全80集虞芙与前男友傅景渊争执时意外穿越，进入一个以丑为尊、美男受歧视的世界。她成为忧郁美男霍自山的助理，需完成帮助美男解开心结任务以返回原世界。虞芙帮助霍自山对抗歧视、提升好感度，期间傅景渊也穿越而来并靠“丑化”成为红人。在经历退婚风波、赢得霍母认可后，虞芙成功帮助霍自山，解锁新目标天才医生沈银川，开启新的挑战。
6.0全35集许婉流产后，被丈夫唐骏哄骗去伺候“客户”董佳倩坐月子，却发现董佳倩是唐骏的小三，孩子也属唐骏。唐骏不仅与董家母女联手羞辱许婉，还承认是他下药导致许婉流产。许婉的哥哥许宸早已察觉真相，暗中保护妹妹
9.0全81集民国时期的医学生程曼卿，意外救下青帮大佬傅砚洲并和他相爱。程曼卿本是一个柔弱娇贵的女孩，却被傅砚洲养成独当一面的黑帮大嫂。她以为会和傅砚洲一直相爱，却不料，傅砚洲渐渐厌弃了她，爱上了单纯的温以眠。为了给温以眠名分，傅砚洲将她残害致死。程曼卿重生一世，发誓绝不再为傅砚洲动情，而是利用所擅长的医学，拯救一城百姓，为国家和社会做贡献。
8.0全60集酒吧老板林雪之因为怀孕无法伺候大佬，于是设计把在自己酒吧做兼职的大学生苏婉晴送到大佬李强的床上，不料，苏婉晴却意外走错房间，和中了迷情药的顾氏集团总裁顾承泽一夜欢好。